产品概述

Anti-Tau pS422 clone 2H9 antibody (4BDX-1501) recognizes the phosphorylated serine 422 of Tau proteins and is suitable for Western Blot, for Immunohistochemistry, Immunofluorescence and Immunotherapy. This antibody was produced from a mouse hybridoma resulting from a mouse immunized with a peptide covering the human Tau protein sequence with the phospho-serine 422. This product is determined by its ability to recognise human Tau phosphorylated at serine 422. Tau proteins are encoded by a single gene MAPT (Gene ID: 4137). They belong to the family of microtubule-associated proteins. The phosphorylation of Tau protein at serine 422 is a pathological epitope and a specific marker of neurofibrillary degeneration, one of the neuropathological hallmark of Alzheimer's disease and also found in more than 20 Tauopathies. On cerebral tissue, frozen or paraffin embedded tissue, 2H9 Tau antibody detects neurons in neurofibrillary degeneration. The serine 422 is phosphorylated by the following kinases: CaMKII (Calcium Calmodulin-kinase II), PKA (protein kinase A), JNKs (c-Jun N-terminal kinases), ERK1/2 or p42/44 MAKP (mitogen-activated kinases), p38 MAPK and MARK (Microtubule-associated protein/microtubule affinity-regulating kinase). The phosphorylation of Tau protein at serine 422 is a pathological epitope and a marker of neurofibrillary degeneration, one of the neuropathological hallmark of Alzheimer's disease. On cerebral tissue sections, Anti-Tau pS422 clone 2H9 antibody (4BDX-1501) detects specifically neurons engaged in neurofibrillary degeneration. According to the literature, the serine 422 is phosphorylated by the following kinases: CaMKII (Calcium Calmodulin-kinase II), PKA (protein kinase A), JNKs (c-Jun N-terminal kinases), ERK1/2 or p42/44 MAKP (mitogen-activated kinases), p38 MAPK and MARK (Microtubule-associated protein/microtubule affinity-regulating kinase).