产品概述

The anti-APP antibody [pT668] recognizes the phosphorylated threonine 668 of Amyloid Protein Precursor (APP). This antibody is suitable for Western Blot, for Immunohistochemistry and Immunofluorescence. This polyserum was obtained by immunizing a rabbit with a 12 amino acid peptide containing the phosphorylated threonine 668 (YVDAAVTPEERH). This antibody is determined by its ability to recognize human APP phosphorylated at threonine 668.Amyloid protein precursor also called APP (Gene ID: 351) is a type 1 transmembrane protein whose metabolism leads to the production of amyloid-beta peptides. In Alzheimer’s disease, amyloid peptides are the main components of amyloid deposits. Phosphorylation of APP at threonine 668 is increased in Alzheimer’s disease and promotes amyloid-beta peptide production. The threonine 668 is phosphorylated by CDK5 (cyclin dependent kinase 2), JNKs (c-Jun N-terminal kinases) and GSK3 (glycogen synthase kinase 3) and DYRK1A (Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A).